中國(guó)科學(xué)技術(shù)大學(xué)學(xué)士、康奈爾大學(xué)博士，中盛溯源生物科技有限公司聯(lián)合創(chuàng)始人、首席技術(shù)官（CTO）。主要研究?jī)?nèi)容：利用重編程、定向分化、和基因修飾等技術(shù)。開(kāi)發(fā)hiPSC來(lái)源細(xì)胞藥物開(kāi)發(fā)，參與承接科技部十三五和十四五國(guó)家重點(diǎn)研發(fā)計(jì)劃《干細(xì)胞制劑及應(yīng)用的標(biāo)準(zhǔn)化研究》和《干細(xì)胞及相關(guān)產(chǎn)品質(zhì)量控制及評(píng)價(jià)技術(shù)》，建立中國(guó)人群“超級(jí)供體”hiPSC庫(kù)、參與起草國(guó)內(nèi)首個(gè)《人誘導(dǎo)多能干細(xì)胞》標(biāo)準(zhǔn)、完成臨床級(jí)hiPSC建庫(kù)質(zhì)量復(fù)核。2022年9月首個(gè)iPSC來(lái)源間充質(zhì)樣細(xì)胞治療產(chǎn)品“NCR100注射液”獲得國(guó)家藥品監(jiān)督管理局藥品審評(píng)中心的臨床試驗(yàn)?zāi)驹S可。
1． hiPSC向體節(jié)中胚層細(xì)胞分化，開(kāi)發(fā)iMSC等細(xì)胞治療產(chǎn)品；
2． hiPSC向血液譜系分化，開(kāi)發(fā)iNK等腫瘤免疫治療產(chǎn)品；
3． hiPSC向特定神經(jīng)祖細(xì)胞分化，開(kāi)發(fā)面向帕金森等神經(jīng)退行性疾病的細(xì)胞治療產(chǎn)品。
發(fā)表論文和專(zhuān)利
1. Zhang H, Su B, Jiao L, Xu ZH, Zhang CJ, Nie J, Gao ML, Zhang YV#, Jin ZB#. Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China. Ann Transl Med. 2021 Feb;9(3):245. (#Corresponding)
2. Yu J, Zhao T, Ma A, Zhang Y, Zhang K, Cheng L, Deng H, Kang J, Jin Z, Pan G, Hao J, Zhang Y, Fu B, Hu S, Na J, Liu Y, Cao J, Wang L, Zhu H. 《人誘導(dǎo)多能干細(xì)胞團(tuán)體標(biāo)準(zhǔn)》，中國(guó)細(xì)胞生物學(xué)會(huì)，2021 Jan.
3. 一種中腦多巴胺能神經(jīng)前體細(xì)胞及其制備方法和應(yīng)用, 專(zhuān)利申請(qǐng)?zhí)?01910169525.0
4. 視網(wǎng)膜色素上皮細(xì)胞及其制備方法和應(yīng)用，專(zhuān)利申請(qǐng)?zhí)?01910320076.5.
5. 一種腎上皮細(xì)胞及其制備方法和應(yīng)用，專(zhuān)利申請(qǐng)?zhí)?01910834502.7.
6. 一種間充質(zhì)干細(xì)胞及其制備方法和應(yīng)用，專(zhuān)利號(hào)ZL201910884482.4.
7. 一種微環(huán)游離型載體高效重編程血液細(xì)胞生成iPSC的方法, 專(zhuān)利號(hào)ZL201810252408.6
8. 一種通過(guò)蠑螈Oct4將人類(lèi)血液細(xì)胞重編程為iPSC的方法, 專(zhuān)利號(hào)ZL201810137319.7 9. Wang AB, Zhang YV, and Tumbar T. (2017) Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. EMBO J. 2017 Jan 4;36(1):61-78.
10. Lee J, Kang S, Lilja K, Colletier K, Scheitz C, Zhang YV, and Tumbar T. (2016) Signaling couples hair follicle stem cell quiescence with reduced H3K4/K9/K27me3 levels for proper tissue homeostasis. Nature Communications 2016 Apr 15;7:11278
11. Zhang YV, Johns L., Yu J. (2014) Generation of keratinocytes from pluripotent stem cells and maintenance of keratinocyte cultures. US Patent CDIN.P0055US.P1.
12. Zhang YV, White B.S., Shalloway D.I., Tumbar T. (2010) Stem cell dynamics in mouse hair follicles: a story from cell division counting and single cell lineage tracing. Cell Cycle 2010 Apr 19;9(8).
13. Zhang YV, Cheong J., Ciapurin N., McDermitt D.J., Tumbar T. (2009) Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell, Volume 5, Issue 3, 267-278.
14. Waghmare S.K., Bansal R., Lee J.*, Zhang YV*, McDermitt D.J., Tumbar T. (2008) Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells. EMBO J. 27(9):1309-20. (* equal contribution)
15. Osorio, K.M., Lee, S.E., McDermitt, D.J., Waghmare, S.K., Zhang, YV, Woo, H.N. Tumbar, T. (2008) Acute Myeloid Leukemia Factor 1 Controls Developmental but not Injury Driven Activation of Hair Follicle Stem Cells. Development, 135, 1059-1068.
16. Yao X., Zhang Y., Chen W., Dou Z. (2005) Patent: A new developed absorbent polymer for protein condensation. The State Intellectual Property Office of the People's Republic of China Patent No.: ZL200310106547.1
17. Dou Z., Ding X., Zereshki A., Zhang Y., Zhang J., Wang F., Sun J., Huang H., Yao X. (2004) TTK kinase is essential for the centrosomal localization of TACC2. FEBS Lett, 572: 51–56.
